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E3 ubiquitin-protein ligase RING2 is an enzyme that in humans is encoded by the RNF2 gene.cite-ref-pmid11513855-5-0[5]cite-ref-entrez-6-0[6]

Polycomb group (PcG) of proteins form the multiprotein complexes that are important for the transcription repression of various genes involved in development and cell proliferation. The protein encoded by this gene is one of the PcG proteins. It has been shown to interact with, and suppress the activity of, transcription factor CP2 (TFCP2/CP2). Studies of the mouse counterpart suggested the involvement of this gene in the specification of anterior-posterior axis, as well as in cell proliferation in early development. This protein was also found to interact with huntingtin interacting protein 2 (HIP2), an ubiquitin-conjugating enzyme, and possess ubiquitin ligase activity.cite-ref-entrez-6-1[6]

• Interactions

• See also

• References

• Further reading

• External links

RNF2 has been shown to interact with TFCP2cite-ref-pmid11865070-7-0[7] and HIP2.cite-ref-pmid11513855-5-1[5]

• RING finger domain

cite-note-refgrch38ensembl-11. GRCh38: Ensembl release 89: ENSG00000121481 – Ensembl, May 2017

cite-note-refgrcm38ensembl-22. GRCm38: Ensembl release 89: ENSMUSG00000026484 – Ensembl, May 2017

cite-note-33. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

cite-note-44. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

cite-note-pmid11513855-55. ↑ citerefleechoisungpark2001Lee SJ, Choi JY, Sung YM, Park H, Rhim H, Kang S (August 2001). "E3 ligase activity of RING finger proteins that interact with Hip-2, a human ubiquitin-conjugating enzyme". FEBS Lett. 503 (1): 61–4. doi:10.1016/S0014-5793(01)02689-8. PMID 11513855. S2CID 42977319.

cite-note-entrez-66. ↑ "Entrez Gene: RNF2 ring finger protein 2".

cite-note-pmid11865070-77. ↑ citereftuckfieldclouston-david-rwilanowski-tomasz-mzhao-lin-lin2002Tuckfield A, Clouston David R, Wilanowski Tomasz M, Zhao Lin-Lin, Cunningham John M, Jane Stephen M (March 2002). "Binding of the RING polycomb proteins to specific target genes in complex with the grainyhead-like family of developmental transcription factors". Mol. Cell. Biol. 22 (6): 1936–46. doi:10.1128/MCB.22.6.1936-1946.2002. ISSN 0270-7306. PMC 135618. PMID 11865070.

• citerefgarc-amarcos-guti-rrezdel-mar-lorente1999García E, Marcos-Gutiérrez C, del Mar Lorente M, et al. (1999). "RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1". EMBO J. 18 (12): 3404–18. doi:10.1093/emboj/18.12.3404. PMC 1171420. PMID 10369680.

• citereftuckfieldcloustonwilanowski2002Tuckfield A, Clouston DR, Wilanowski TM, et al. (2002). "Binding of the RING polycomb proteins to specific target genes in complex with the grainyhead-like family of developmental transcription factors". Mol. Cell. Biol. 22 (6): 1936–46. doi:10.1128/MCB.22.6.1936-1946.2002. PMC 135618. PMID 11865070.

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• citerefsuzukimizutani-kosekifujimura2002Suzuki M, Mizutani-Koseki Y, Fujimura Y, et al. (2002). "Involvement of the Polycomb-group gene Ring1B in the specification of the anterior-posterior axis in mice". Development. 129 (18): 4171–83. doi:10.1242/dev.129.18.4171. PMID 12183370.

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• citerefleechoirhimkang2005Lee SJ, Choi D, Rhim H, Kang S (2005). "E3 ubiquitin ligase RNF2 interacts with the S6' proteasomal ATPase subunit and increases the ATP hydrolysis activity of S6'". Biochem. J. 389 (Pt 2): 457–63. doi:10.1042/BJ20041982. PMC 1175123. PMID 15773819.

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• RNF2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)